Endocrine Abstracts

The incidence of type 1A diabetes has been doubling approximately every two decades in multiple developed countries. This implies important environmental determinants that are either increasing or decreasing and influencing overall incidence. Recent studies indicate that extreme genetic risk can be defined for major defined genetic subsets. For instance, siblings of a patient with type 1A diabetes who have the highest risk HLA alleles DR3/4-DQ2/8 and in addition have inherited...

Background: Data examining HLA associations in Addison’s disease (AD) from South Africa (SA) are limited. We wished to determine the HLA in South African AD patients either positive or negative for 21 hydroxylase autoantibodies (21 OH-AA) and matched healthy controls, hypothesising that certain HLA alleles could predominate, but there may be differences from Western countries.Methods: SA patients (n=73) were enrolled as part of a nationwide...